257930-74-8
中文名稱
亞麻木酚素
英文名稱
Secoisolariciresinol diglucoside
CAS
257930-74-8
分子式
C32H46O16
分子量
686.7
MOL 文件
257930-74-8.mol
更新日期
2024/11/13 13:52:26
257930-74-8 結(jié)構(gòu)式
基本信息
中文別名
(S,S)-亞麻木酚素 英文別名
β-D-Glucopyranoside, (2S,3S)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl bis- 所屬類別
天然產(chǎn)物：木脂素物理化學(xué)性質(zhì)
沸點(diǎn)989.2±65.0 °C(Predicted)
密度1.52±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)9.80±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Secoisolariciresinol diglucoside ((S,S)-SDG) 是全麥亞麻籽中的主要木脂素，具有抗炎，抗氧化，抗誘變，抗微生物，抗肥胖，降血脂和神經(jīng)保護(hù)作用。體外研究
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.
Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers.
體內(nèi)研究
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.
| Animal Model: | Hand feeding mice (10 weeks old, male) are injected with TNFα |
| Dosage: | 4 mg/mouse |
| Administration: | P.o. 2 h before i.c. administration of TNFα |
| Result: | Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%. |