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24730-31-2

中文名稱 表面活性劑SURFACTIN
英文名稱 SURFACTIN
CAS 24730-31-2
分子式 C53H93N7O13
分子量 1036.34
MOL 文件 24730-31-2.mol
更新日期 2025/01/09 10:25:43
24730-31-2 結(jié)構(gòu)式 24730-31-2 結(jié)構(gòu)式

基本信息

中文別名
表面活性素
表面活性劑SURFACTIN
英文別名
abs9122
SURFACTIN
surfactin C
Surfactin C1
Surfactin peptide
Biosurfactants Surfactin
surfactin from bacillus subtilis
Cyclo(L-α-aspartyl-D-leucyl-L-leucyl-3-hydroxy-13-methyltetradecanoyl-L-α-glutamyl-L-leucyl-D-leucyl-L-valyl)
所屬類別
生物化工：生化試劑

物理化學(xué)性質(zhì)

熔點140-144°C
沸點1268.3±65.0 °C(Predicted)
密度1.037±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度ethanol: 10 mg/mL, clear, slightly yellow
酸度系數(shù)(pKa)4.00±0.10(Predicted)
形態(tài)粉末
顏色白色至淡黃色
水溶解性Water: 31.25 mg/mL (30.15 mM)
穩(wěn)定性Stable, but store below 10 C. Incompatible with strong oxidizing agents.

安全數(shù)據(jù)

WGK Germany3

常見問題列表

生物活性
Surfactin 是一種環(huán)狀脂肽生物表面活性劑，可介導(dǎo)單價和二價陽離子 (如鈣離子) 穿過脂質(zhì)雙層膜的通量。Surfactin 可以作為抗微生物佐劑，具有抗菌，抗真菌，抗支原體和溶血作用。Surfactin 還對多種包膜病毒具有抗病毒活性。
靶點

HSV-1

HSV-2

體外研究

Surfactin can increase the activity of NSC277174 against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). For APEC O78 strain, the MIC of NSC277174 and Surfactin are 1000 ug/ml and >1mg/ml, respectively.

體內(nèi)研究

In the model of chick infection (inoculation of E.coli ), Surfactin exerts adjuvant effects with NSC277174 against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. Surfactin can act as a novel antimicrobial adjuvant with NSC277174 against AEPC infection in chicken.

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