247167-54-0
中文名稱
(Z-)-4-BroMo-5-(broMoMethylene)-2(5H)-furanone
英文名稱
(Z-)-4-BroMo-5-(broMoMethylene)-2(5H)-furanone
CAS
247167-54-0
分子式
C5H2Br2O2
分子量
253.88
MOL 文件
247167-54-0.mol
247167-54-0 結(jié)構(gòu)式
基本信息
中文別名
呋喃酮 C-30(Z - )- 4-溴-5-(溴亞甲基)-2(5H)- 呋喃酮
英文別名
Furanone C-30(Z-)-4-BROMO-5-(BROMOMETHYLENE)-2(5H
(5Z)-4-Bromo-5-(bromomethylene)-2(5H)-furanone
(Z-)-4-BroMo-5-(broMoMethylene)-2(5H)-furanone
2(5H)-Furanone, 4-bromo-5-(bromomethylene)-, (5Z)-
(Z-)-4-Bromo-5-(bromomethylene)-2(5H)-furanone >=97.0% (GC)
物理化學(xué)性質(zhì)
熔點97-99 °C
沸點205.9±40.0 °C(Predicted)
密度2.650±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
BRN120928
常見問題列表
生物活性
Furanone C-30 是一種細菌 (bacterial) 群體感應(yīng)抑制劑。Furanone C-30 可有效抑制細菌 (如 S. mutans 及其 luxS 突變株) 生物膜形成。靶點
Bacterial biofilm
體外研究
The difference in the OD590 values is statistically significant at concentrations of 2.0 μg/mL and 4.0 μg/mL compared with the control group. Furanone C-30 (2.0 μg/mL and 4.0 μg/mL) can inhibit biofilm formation by S. mutans and its luxS mutant strain, although it does not affect the bacterial growth rate itself.
Cell Viability Assay
| Cell Line: | Streptococcus mutans UA159 and its luxS mutant strain |
| Concentration: | 0.0, 2.0 and 4.0 μg/mL |
| Incubation Time: | 24 hours |
| Result: | When 2.0 μg/mL was added, the OD590 values for S. mutans and its luxS mutant strain decreased by 42.7% and 40.8%, respectively. When the concentration was increased to 4.0 μg/mL, a decrease of 61.5% and 60.3%, respectively. |