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235433-36-0

中文名稱 THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
英文名稱 H-SER-ARG-THR-HIS-ARG-HIS-SER-MET-GLU-ILE-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
CAS 235433-36-0
分子式 C104H158N32O26
分子量 2272.57
MOL 文件 235433-36-0.mol
更新日期 2024/10/20 11:23:33
235433-36-0 結(jié)構(gòu)式 235433-36-0 結(jié)構(gòu)式

基本信息

中文別名
催乳素釋放肽人
12-31-人催乳素釋放肽
PROLACTIN-RELEASING肽(1-31) (人)
英文別名
PRRP20
PRRP31
PRRP20 (HUMAN)
PRRP31 (HUMAN)
TPDINPAWYASRGIRPVGRF-NH2
PREPROLACTIN (23-53) (HUMAN)
PREPROLACTIN (34-53) (HUMAN)
PROLACTIN-RELEASING PEPTIDE (1-31)
SRTHRHSMEIRTPDINPAWYASRGIRPVGRF-NH2
PROLACTIN-RELEASING PEPTIDE (HUMAN)

物理化學(xué)性質(zhì)

密度1.50±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3
THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-P1530THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
Prolactin Releasing Peptide (12-31), human
235433-36-0500μg1800元
2024/08/19HY-P1530THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
Prolactin Releasing Peptide (12-31), human
235433-36-01mg3120元
2024/08/19HY-P1520THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
Prolactin Releasing Peptide (1-31), human
235433-36-0500μg2200元

常見(jiàn)問(wèn)題列表

生物活性
Prolactin Releasing Peptide (12-31), human是催乳素釋放肽的片段。Prolactin Releasing Peptide (1-31), human是高親和力的 GPR10 配體,其引起催乳素的釋放。
靶點(diǎn)

GPR10

體外研究

The Prolactin Releasing Peptide (PrRP) is a C-terminally amidated, 31-amino acid peptide derived from a 98-amino acid precursor. Radioiodinated PrRP-(1-31) binds to its receptor with high affinity (1 nM) and stimulates calcium mobilization in CHOK1 cells stably transfected with the receptor. A series of N-terminal deletions reveals that the Prolactin Releasing Peptide (12-31) amino acid is equipotent to PrRP-(1-31). Further N-terminal deletions reduce the affinity of the ligand considerably. Prolactin Releasing Peptide (PrRP) has been identified as a specific, high affinity endogenous ligand for GPR10. Prolactin Releasing Peptide (PrRP) preproprotein can be cleaved at two different positions to give rise to two forms of 31 or 20 amino acids; Prolactin Releasing Peptide (PrRP)-31 and Prolactin Releasing Peptide (PrRP)-20 respectively. Rat Prolactin Releasing Peptide (PrRP) has also been identified and occurs as 31 or 20 amino acid forms; these peptides are highly conserved between species. Human PrRP‐20, human PrRP‐31, rat PrRP‐20 and rat PrRP‐31 display high affinity for GPR10 receptors, with K i values of 0.26±0.07, 1.03±0.41, 0.22±0.06 and 0.33±0.11 nM, respectively.

體內(nèi)研究

Following intracerebroventricular injection of Prolactin Releasing Peptide (1-31), human 5 nM there is a highly significant simulation of plasma LH that began at 10 minutes and is maintained over the course of the experiment. Plasma FSH increased at 20 minutes following ICV injection. Total plasma testosterone increased at 60 minutes post injection.

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