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23491-44-3

中文名稱 CELLSTAIN- HOECHST 33258 SOLUTION
英文名稱 HOECHST 33258
CAS 23491-44-3
分子式 C25H24N6O
分子量 424.5
MOL 文件 23491-44-3.mol
23491-44-3 結(jié)構(gòu)式 23491-44-3 結(jié)構(gòu)式

基本信息

中文別名
CELLSTAIN- HOECHST 33258 SOLUTION
英文別名
pibenzimol
Bisbenzimidazol
bisbenzimidazole
BISBENZIMIDE H 33258
hoechst 33258 (bisbenzimide)
bis-benzimide (hydroxyphenyl form)
BISBENZIMIDE TRIHYDROCHLORIDE HYDRATE
bisbenzimide trihydrochloride cell*culture tested
4-[6'-(4-Methylpiperazino)-6,2'-bi[1H-benzimidazole]-2-yl]phenol
4-[5-(4-methyl-1-piperazinyl)[2,5’-bi-1h-benzimidazol]-2’-yl]-pheno

物理化學(xué)性質(zhì)

熔點314 °C
沸點746.9±70.0 °C(Predicted)
密度1.355±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度H2O: 10 mg/mL
酸度系數(shù)(pKa)9.23±0.15(Predicted)
形態(tài)powder
顏色Light yellow to yellow
穩(wěn)定性穩(wěn)定的。與強氧化劑不相容。對光敏感。

安全數(shù)據(jù)

危險品標(biāo)志Xn
危險類別碼22-36/38
安全說明26-36
WGK Germany3
RTECS號SM1140500

常見問題列表

生物活性
Hoechst 33258是一種熒光染料,當(dāng)與 dsDNA 結(jié)合時會發(fā)出藍色熒光。
靶點

IC50: 51.31±4.56 μM (HeLa cell), 32.43±3.27 μM (HL60 cell), 15.42 ± 2.16 μM (U937 cell)

體外研究

Hoechst 33258, a fluorescent compound with a head-to-tail bis-benzimidazole structure, is initially found to be cytotoxic against L1210 murine leukemia. Hoechst 33258 is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), Human promyelocytic leukemia cell (HL60) and U937 cell Line. The IC 50 determined in the case of HeLa, HL60 and U937 is 51.31±4.56, 32.43±3.27 and 15.42±2.16 μM for Hoechst 33258, respectively. The cytotoxic property of Hoechst 33258 is investigated on a panel of seven tumour cell lines of different histological origin and Madine-Darby canine kidney (MDCK) normal cells. All cell lines, except MCF-7, exposed to Hoechst 33258 exhibit GI 50 from 84×10 -6 to 191.5×10 -6 mol/dm 3 . Under the same experimental conditions, Hoechst 33258, used as a binder reference compound, stops the cell cycle in S phase and G0/G1.

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