2342583-66-6
中文名稱
NCC007游離態(tài)
英文名稱
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
CAS
2342583-66-6
分子式
C22H28F3N7
分子量
447.5
MOL 文件
2342583-66-6.mol
更新日期
2023/02/22 11:54:00
2342583-66-6 結(jié)構(gòu)式
基本信息
中文別名
化合物NCC007NCC007游離態(tài)
英文別名
9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)573.5±60.0 °C(Predicted)
密度1.36±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)9.02±0.28(Predicted)
形態(tài)Solid
顏色White to off-white
NCC007游離態(tài)價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2023/01/06 | S0811 | NCC007游離態(tài) NCC007 | 2342583-66-6 | 5mg | 2514.33元 |
| 2023/01/06 | S0811 | NCC007游離態(tài) NCC007 | 2342583-66-6 | 25mg | 7608.51元 |
常見問題列表
生物活性
NCC007 是一種雙酪蛋白激酶 Iα (CKIα) 和 δ (CKIδ) 抑制劑，IC50 分別為 1.8 和 3.6 μM。NCC007 可用于哺乳動物晝夜節(jié)律的研究。靶點(diǎn)
|
CKIα 1.8 μM (IC 50 ) |
CKIδ 3.6 μM (IC 50 ) |
體內(nèi)研究
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.
| Animal Model: | Adult C57BL/6J background male mice (8 weeks old) |
| Dosage: | 5, 15 mM |
| Administration: | Infused into the lateral ventricle, constant dark condition |
| Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. |