2310135-18-1
中文名稱
N-deacetylated BMS-202
英文名稱
N-deacetylated BMS-202
CAS
2310135-18-1
分子式
C23H27N3O2
分子量
377.48
MOL 文件
2310135-18-1.mol
2310135-18-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12143 英文別名
N-deacetylated BMS-2021,2-Ethanediamine, N1-[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)529.1±45.0 °C(Predicted)
密度1.127±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9.45±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
N-deacetylated BMS-202是BMS-202的脫乙?；MS-202是PD-l/PD-Ll相互作用的抑制劑，主要用于癌癥研究。體外研究
BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems.