229961-08-4
中文名稱
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
英文名稱
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
CAS
229961-08-4
分子式
C64H103N21O14S
分子量
1422.7
MOL 文件
229961-08-4.mol
更新日期
2024/12/22 20:23:42
229961-08-4 結(jié)構(gòu)式
基本信息
中文別名
RF-12 英文別名
APELIN 12RPRLSHKGPMPF
Apelin-12,(Des-Gln1)-Apelin-13
APELIN-12 (HUMAN, BOVINE, MOUSE, RAT)
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
PREPROAPELIN (66-77) (HUMAN, BOVINE, MOUSE, RAT)
(DES-GLN1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT)
Apelin-12 (human, bovine, mouse, rat) H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
物理化學(xué)性質(zhì)
RTECS號CD7310000
儲存條件-15°C
形態(tài)凍干粉
顏色White to off-white
序列H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
常見問題列表
生物活性
Apelin-12 是多肽中最有效的 C 端片段之一，對孤兒受體 APJ 受體具有很高的親和力。Apelin-12 參與體液平衡的調(diào)節(jié)和攝食的中樞控制。Apelin-12 阻斷HIV-1通過 APJ 受體進(jìn)入。Apelin-12 具有神經(jīng)保護(hù)作用。體外研究
Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse.
Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents.
Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs.