220334-14-5
中文名稱
Volixibat potassium
英文名稱
Volixibat potassium
CAS
220334-14-5
更新日期
2025/01/08 09:19:39
分子式
C39H62N10O15
分子量
910.98
MOL 文件
220334-14-5.mol
220334-14-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T26629單鏈尿激酶纖溶酶原激活劑多肽
單鏈尿激酶纖溶酶原激活劑八肽
英文別名
A-6 peptideVolixibat potassium
Angstrom6/A6 Peptide
所屬類(lèi)別
生物化工：多肽物理化學(xué)性質(zhì)
沸點(diǎn)1469.3±65.0 °C(Predicted)
密度1.409±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)4.44±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Angstrom6 (A6 Peptide) 是一種來(lái)源于單鏈尿激酶纖溶酶原激活劑 (scuPA) 的8個(gè)氨基酸的肽，可干擾 uPA/uPAR 級(jí)聯(lián)反應(yīng)并消除下游效應(yīng)。Angstrom6 與 CD44 結(jié)合，抑制腫瘤細(xì)胞的遷移、侵襲和轉(zhuǎn)移，調(diào)節(jié) CD44 介導(dǎo)的細(xì)胞信號(hào)。體外研究
Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC
50
s in the range of 10 to 100 nM.
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation.
體內(nèi)研究
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%.
| Animal Model: | C57Bl/6 mice (bearing B16-F10 cells) |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; twice a day for 11 days |
| Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |