219944-46-4
中文名稱
異七葉皂苷 IB
英文名稱
Isoescin IB
CAS
219944-46-4
分子式
C55H86O24
分子量
1131.26
MOL 文件
219944-46-4.mol
更新日期
2024/11/02 12:10:52
219944-46-4 結(jié)構(gòu)式
基本信息
中文別名
異七葉皂苷 IB異七葉樹皂苷IB
七葉皂苷D(異七葉皂苷IB)
英文別名
Aescin DEscin IVb
Isoescin Ib
Isoescin IB(Isoaescin IB)
Escin Impurity 4（Isoescin IB）
β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-28-(acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
(3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid
常見問題列表
生物活性
Isoescin IB 是從七葉樹種子中分離出來的，Isoescin IB 是 Escin IB 的異構(gòu)體。Isoescin IB 和 Escin IB 是 Escin 中的主要活性成分。體外研究
β-Escin (mainly consisting of escin Ia and escin Ib) is the major active ingredient in horse chestnut seeds extracts. β-escin can inhibit proliferation and/or induce apoptosis in various types of cancer cells including A549 cell, HT-29 cell, HCC cell, OVCAR3 cell and H-Ras 5RP7 cell. β-escin may be useful as a chemopreventive agent, especially for tumors associated with an inflammatory response.
As the minor component of escin, α-escin (mainly consisting of isoescin Ia and isoescin Ib) exhibits lower bioactivity.