219832-49-2
219832-49-2 結(jié)構(gòu)式
基本信息
中文別名
SK抑制劑(MP-A08) 英文別名
MP-A084-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)717.1±70.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
溶解度DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
酸度系數(shù)(pKa)7.88±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
219832-49-2價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 1mg | 350元 |
| 2024/11/08 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 5mg | 550元 |
| 2024/11/08 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 10mg | 900元 |
常見問題列表
生物活性
MP-A08 是一個(gè)高度選擇性的 ATP 競爭性的 SPHK1 抑制劑。體外研究
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]
體內(nèi)研究
MP-A08 suppresses the growth of human lung tumor xenografts in mice.