2173232-79-4
2173232-79-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點386.2±42.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)3.04±0.20(Predicted)
形態(tài)Solid
顏色Pink to red
常見問題列表
生物活性
LOM612 有效對 FOXO 胞質(zhì)-胞核穿梭進(jìn)行定位，在 U2fox RELOC 細(xì)胞中 EC50 值為 1.5 μM。靶點
EC50: 1.5 μM (FOXO, in U2fox RELOC cells)
體外研究
LOM612 potently activates nuclear translocation of FOXO with an EC 50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC 50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC 50 , 2.76 μM).