2172617-16-0
中文名稱
YKL-06-062
英文名稱
YKL-06-062
CAS
2172617-16-0
分子式
C31H39N7O
分子量
525.69
MOL 文件
2172617-16-0.mol
更新日期
2023/03/20 15:41:23
2172617-16-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T17272 英文別名
YKL-06-062Pyrimido[4,5-d]pyrimidin-2(1H)-one, 1-cyclohexyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
物理化學(xué)性質(zhì)
沸點(diǎn)706.2±70.0 °C(Predicted)
密度1.229±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)7.90±0.42(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
YKL-06-062 is a second-generation SIK inhibitor. YKL 06-062 induces significant pigmentation after 8 days of treatment (1×/day). YKL 06-062 did not require mechanical application (rubbing) to induce significant human epidermal darkening. YKL-06-062 induces not only synthesis of melanin but also melanosomal maturation, export, and localization features, even after import into keratinocytes.