216064-36-7
中文名稱
POMPILIDOTOXIN, -
英文名稱
BETA-POMPILIDOTOXIN
CAS
216064-36-7
分子式
C71H124N22O17
分子量
1557.88
MOL 文件
216064-36-7.mol
216064-36-7 結(jié)構(gòu)式
基本信息
中文別名
Β-絨毛膜毒素Β-PMTX 英文別名
β-PMTXBETA-PMTX
β-Pompilidotoxin
b-Pompilidotoxin
RIKIGLFDQLSRL-NH2
BETA-POMPILIDOTOXIN
L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl-
物理化學(xué)性質(zhì)
儲(chǔ)存條件−20°C
溶解度≥155.8 mg/mL in DMSO; insoluble in EtOH; ≥22.05 mg/mL in H2O
形態(tài)固體
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
常見問題列表
生物活性
β-Pompilidotoxin (β-PMTX) 是一種黃蜂毒液，可以減緩鈉通道 (sodium channel) 的失活并增加細(xì)胞中的穩(wěn)態(tài)鈉電流。體外研究
β-Pompilidotoxin (β-PMTX) increases resurgent current in wild-type neurons and induced resurgent current in med neurons. β-Pompilidotoxin (10 μM) modestly but significantly increased the decay time constant (τ decay ) of currents evoked by a step from -90 to 0 mV from 0.52 to 0.73 msec in wild-type Purkinje cells.