2136278-38-9
英文名稱
2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl-
CAS
2136278-38-9
分子式
C20H16ClF3N6O2
分子量
464.83
MOL 文件
2136278-38-9.mol
2136278-38-9 結(jié)構(gòu)式
基本信息
英文別名
2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl-應(yīng)用領(lǐng)域
用途一
DCZ3301 is an aryl-guanidino inhibitor that induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. DCZ3301 induces G2/M cell cycle arrest, and associates with downregulation of CDK1, cyclin B1, and cdc25C. DCZ3301 also induces cell apoptosis by decreasing MMP in T-cell leukemia/lymphoma cells.