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2109805-75-4

中文名稱 2109805-75-4
英文名稱 CU-CPT17e
CAS 2109805-75-4
分子式 C27H24N2O8
分子量 504.49
MOL 文件 2109805-75-4.mol
更新日期 2024/06/07 17:53:08
2109805-75-4 結(jié)構(gòu)式 2109805-75-4 結(jié)構(gòu)式

基本信息

中文別名
化合物CU-CPT17E
英文別名
CU-CPT17e
Spiro[2H-1-benzopyran-2,4'-[4H]pyran], 2',3',5',6'-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 5 mg/mL (9.91 mM)
形態(tài)Solid
顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
2109805-75-4價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-1019292109805-75-4
CU-CPT17e
2109805-75-41mg2100元
2024/11/08HY-1019292109805-75-4
CU-CPT17e
2109805-75-45mg4400元
2024/08/19HY-1019292109805-75-4
CU-CPT17e
2109805-75-410mg6600元

常見問題列表

生物活性
CU-CPT17e 是一種有效的多 Toll 樣受體 (TLR) 激動(dòng)劑,可激活 TLR3,TLR8 和 TLR9。
靶點(diǎn)

TLR3

TLR8

TLR9

體外研究

CU-CPT17e shows strong NF-κB activation in TLR3, TLR8 and TLR9 HEK293 cells with EC 50 values of 4.80±0.73, 13.5±0.58 and 5.66±0.17 μM, respectively. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC 50 value of 4.8±0.7 μM. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. The induction of apoptosis by CU-CPT17e in HeLa cells is investigated. HeLa cells are cultured with increasing concentrations of CU-CPT17e or poly I:C or blank control (DMSO) for 24 h. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL. These results suggest that the antiproliferative activity of CU-CPT17e against HeLa cells might result from its ability to directly induce apoptosis.

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