2097262-60-5
中文名稱
FASN inhibitor 1
英文名稱
FASN inhibitor 1
CAS
2097262-60-5
分子式
C24 H24 N4 O
分子量
384.47
MOL 文件
2097262-60-5.mol
2097262-60-5 結(jié)構(gòu)式
基本信息
中文別名
化合物FASN-IN-3 英文別名
FASN-IN-3FASN inhibitor 1
Benzonitrile, 4-[1-[5-(3,4-dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)641.5±55.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)14.66±0.50(Predicted)
形態(tài)Solid
顏色Off-white to yellow
常見問題列表
生物活性
FASN-IN-3 是一種脂肪酸合酶 (FASN) 抑制劑，詳細(xì)信息請(qǐng)參考專利文獻(xiàn) US20170119786A1 中的化合物 242A。靶點(diǎn)
FASN
體外研究
Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN-IN-3 (Compound 242A), results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. For monocytes, FASN-IN-3 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation.