2089-82-9
2089-82-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 5 mg/mL (20.30 mM)
沸點(diǎn)522.2±15.0 °C(Predicted)
密度1.393±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)7.15±0.30(Predicted)
形態(tài)Solid
顏色Yellow to orange
常見(jiàn)問(wèn)題列表
生物活性
sAJM589 是一種 Myc 抑制劑，能干擾 Myc- max 異二聚體的形成，其 IC50 值為 1.8 μM。靶點(diǎn)
IC50: 1.8 μM (Myc)
體外研究
sAJM589 potently disrupts the Myc-Max heterodimer to reduce Myc protein levels in a dose dependent manner, with an IC
50
of 1.8 μM.
sAJM589 suppresses cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells.