2079895-62-6
2079895-62-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.31±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度可溶于DMSO
酸度系數(shù)(pKa)14.98±0.20(Predicted)
形態(tài)固體
顏色Light yellow to yellow
常見問題列表
生物活性
TP-472 是一種選擇性的 BRD7/9 抑制劑，對 BRD7 和 BRD9 作用的 KD 值分別為 0.34 μM 和 33 nM。靶點
|
BRD7 0.34 μM (Kd) |
BRD9 33 nM (Kd) |
體外研究
TP-472 has a high potency for BRD9 (K
d
= 33 nM) and BRD7 (K
d
= 0.34 μM), with >30-fold selectivity over other Brds.
TP-472 (1 μM, 3 μM; 24-216 hours) yields concentration-dependent growth defects in ESCs.
Cell Viability Assay
| Cell Line: | ESCs |
| Concentration: | 1 μM, 3 μM |
| Incubation Time: | 24 hours, 72 hours, 120 hours, 168 hours, 216 hours |
| Result: | Yields concentration-dependent growth defects in ESCs. |