2070014-93-4
2070014-93-4 結構式
基本信息
HFOZCHHWLMTUTP-UHFFFAOYSA-N
5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole
5-?(3,?5-Dimethyl-?4-?isoxazolyl)?-?1-?[2-?(4-?morpholinyl)?ethyl]?-?2-?[2-?(4-?propoxyphenyl)?ethyl]?-1H-?benzimidazole Hydrochloride
物理化學性質
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 5mg | 500元 |
| 2024/11/08 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 10mg | 750元 |
| 2024/11/08 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 10mM * 1mLin DMSO | 751元 |
常見問題列表
|
CREBBP 125 nM (IC 50 ) |
EP300 363 nM (IC 50 ) |
CBP 0.19 μM (Kd) |
BRD4 20 μM (Kd) |
ITC is the label-free technique for determining K D values, PF-CBP1 is against CBP (K d =0.19 μM) and >105-fold selective over BRD4 (K d >20 μM) by ITC.PF-CBP1 displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins, it against BRD2-1,BRD3-1, BRD3-2,BRD4-1, BRD4-2, BRDT-1, TAF1-2, and TAF1L-2 with IC 50 values of 1.24 μM, 1.38 μM, 4.22 μM, 1.54 μM, 9.75 μM, 2.44 μM, 3.39 μM and 7.29 μM, respectively.PF-CBP1 (3-10 μM; pretreatment 30 mins; 4 hours) moderately reduces LPS-induced IL-6 and IFN-b expression in the J774 cell at 10 μM. And it decreases IL-1b expression evidently at 3 μM.PF-CBP1 (100 nM-1000 nM;24 hours) significantly reduced RGS4 mRNA levels(49% reduction) relative to vehicle in cortical neuron cells.