2058264-32-5
中文名稱
2058264-32-5
英文名稱
TBK1/IKKε-IN-1
CAS
2058264-32-5
分子式
C28H26N4O5
分子量
498.53
MOL 文件
2058264-32-5.mol
2058264-32-5 結(jié)構(gòu)式
基本信息
中文別名
TBK1/IKK&EPSILON-IN-1
英文別名
TBK1/IKKε-IN-1TBK1/IKK&epsilon
6-[7-[3-cyano-4-(oxan-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl]-5-methoxy-N,N-dimethylpyridine-3-carboxamide
常見問題列表
生物活性
TBK1/IKKε-IN-1 是一種雙重 TBK1 和 IKKε 抑制劑，IC50s 值 <100 nM。詳細(xì)信息請(qǐng)參考專利文獻(xiàn) US20160376283 A1 中 Example 60 中的化合物 274。靶點(diǎn)
|
TBK1 100 nM (IC 50 ) |
IKKε 100 nM (IC 50 ) |
體外研究
IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response.