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204592-94-9

中文名稱 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
英文名稱 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
CAS 204592-94-9
分子式 C31H32N4O4
分子量 524.61
MOL 文件 204592-94-9.mol
204592-94-9 結(jié)構(gòu)式 204592-94-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15819
英文別名
LY377604
LY-377604,LY377604
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-

物理化學性質(zhì)

沸點809.4±65.0 °C(Predicted)
密度1.282±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.94±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light brown

常見問題列表

生物活性
LY377604 是一種人類 β3-腎上腺素受體激動劑，其 EC50 值為 2.4 nM，同時也是 β1 和 β2 腎上腺素能受體的拮抗劑。
靶點

EC50: 2.4 nM (human β 3 -adrenergic receptor) β 1 -adrenergic receptor, β 2 -adrenergic receptor

體外研究

LY377604 is a human β 3 -adrenergic receptor agonist with an EC 50 of 2.4 nM and also a β 1 - and β 2 -adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β 1 adrenergic receptor or the human β 2 adrenergic receptor.

體內(nèi)研究

Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.

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