203849-91-6
中文名稱
單甲基澳瑞他汀 D
英文名稱
MonoMethyl Dolastatin 10
CAS
203849-91-6
分子式
C41H66N6O6S
分子量
771.06
MOL 文件
203849-91-6.mol
更新日期
2024/11/05 14:08:38
203849-91-6 結(jié)構(gòu)式
基本信息
中文別名
一甲基澳瑞他汀 D單甲基澳瑞他汀 D
一甲基澳瑞他汀D/MMAD/
微管(TUBULIN)抑制劑(MMAD)
英文別名
MMADCS-1368
EOS-60620
DeMethyldolastatin 10
MonoMethylauristatin D
MonoMethyl Dolastatin 10
Demethyldolastatin (MMAD)
MMAD (Demethyldolastatin 10
DEMETHYLDOLASTATIN 10
MONOMETHYLAURISTATIN D
MONOMETHYL DOLASTATIN 10
N-Methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點906.1±65.0 °C(Predicted)
密度1.119±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Store in freezer, under -20°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.81±0.46(Predicted)
形態(tài)粉末
顏色White to off-white
單甲基澳瑞他汀 D價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-15581 | 單甲基澳瑞他汀 D MMAD | 203849-91-6 | 5mg | 800元 |
| 2024/08/19 | HY-15581 | 單甲基澳瑞他汀 D MMAD | 203849-91-6 | 10mg | 1400元 |
| 2024/08/19 | HY-15581 | 單甲基澳瑞他汀 D MMAD | 203849-91-6 | 50mg | 4500元 |
常見問題列表
生物活性
MMAD 是一種有效的微管 (tubulin) 抑制劑，是抗體藥物偶聯(lián)物 (ADCs) 中的活性分子。靶點
|
Auristatin
|
體外研究
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity.
體內(nèi)研究
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.