20108-30-9
中文名稱(chēng)
殼梭孢(菌)素
英文名稱(chēng)
FUSICOCCIN
CAS
20108-30-9
分子式
C36H56O12
分子量
680.82
MOL 文件
20108-30-9.mol
20108-30-9 結(jié)構(gòu)式
基本信息
中文別名
殼梭孢(菌)素殼梭孢菌素 來(lái)源于扁桃殼梭菌
英文別名
Nsc113500Fucicoccin
FUSICOCCIN
Fusicoccin a
Fusicoccin-A (Fusicoccin
fusicoccin from fusicoccum amygdali
3-[2-(Acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethylcyclopenta[a,d]-dicylo coten-4-yl-6
α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propen-1-yl)-, 3-acetate
.alpha.-D-Glucopyranoside, 3-[2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6A,7,8,9,10A-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10A-dimethyldicyclopenta[A,D]cycloocten-4-yl 6-o-(1,1-dimethyl-2-propenyl)-, 3-acetate, [1S-[1.alpha.,3(R*),4.alpha.,5.beta.,6.beta.,6A.alpha.,9.beta.,10A.beta.]]-
殼梭孢(菌)素價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-122815 | 殼梭孢(菌)素 Fusicoccin | 20108-30-9 | 1mg | 7020元 |
常見(jiàn)問(wèn)題列表
生物活性
Fusicoccin (Fusicoccin A)，一種真菌化膿毒素，14-3-3 蛋白相互作用的穩(wěn)定劑。Fusicoccin 使 H+-ATPase/14-3-3 復(fù)合物在植物中穩(wěn)定，保持酶的激活狀態(tài)。Fusicoccin 還穩(wěn)定 14-3-3 蛋白與含有 C-末端 14-3-3 識(shí)別基序的結(jié)合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 誘導(dǎo)一些癌細(xì)胞調(diào)亡，并具有抗癌活性。體外研究
Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC
50
=29 mM).
Fusicoccin A activates the plasma membrane H
+
-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC
50
growth inhibitory concentration of fusicoccin A is 92 μM in the U373-MG cells and 83 μM in the Hs683 glioma cells.