2003260-55-5
2003260-55-5 結(jié)構(gòu)式
基本信息
KDM4B-IN-B3
NCGC00244536
KDM4B Inhibitor B3
KDM4B INHIBITOR COMPOUND B3
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
物理化學(xué)性質(zhì)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-101799 | 3-(8-羥基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 NCGC00244536 | 2003260-55-5 | 1mg | 1100元 |
| 2024/08/19 | HY-101799 | 3-(8-羥基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 NCGC00244536 | 2003260-55-5 | 10mM * 1mLin DMSO | 2777元 |
| 2024/08/19 | HY-101799 | 3-(8-羥基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 NCGC00244536 | 2003260-55-5 | 5mg | 3100元 |
常見問題列表
IC50: 10 nM (KDM4B)
NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.