200189-97-5
中文名稱
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
英文名稱
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
CAS
200189-97-5
分子式
C19H17NO.C4H4O4
分子量
391
MOL 文件
200189-97-5.mol
200189-97-5 結(jié)構(gòu)式
基本信息
中文別名
奧米加匹馬來(lái)酸鹽 英文別名
CGP3466BCGP-3466B
TCH 346 maleate
CGP 3466B maleate
CGP 3466 (maleate)
TCH 346 MALEATE
CGP3466B
CGP-3466B
TCH346
TCH-346
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
常見(jiàn)問(wèn)題列表
生物活性
Omigapil maleate 是一種具有口服活性的 GAPDH 亞硝基化抑制劑，可消除 Aβ1-42 誘導(dǎo)的小鼠 tau 乙?；?，記憶障礙和運(yùn)動(dòng)功能障礙，Omigapil maleate 具有研究阿爾茨海默癥的潛力。Omigapil maleate (CGP3446B maleate) 是一種有效的凋亡 (apoptosis) 抑制劑。Omigapil maleate 可用于研究先天性肌營(yíng)養(yǎng)不良 (CMD)。靶點(diǎn)
Apoptosis
體內(nèi)研究
Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force.
| Animal Model: | 12-week-old dyW/ mag mice |
| Dosage: | 0.1 mg/kg |
| Administration: |
For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage. |
| Result: |
Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil. |