成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據庫列表>197794-83-5

197794-83-5

中文名稱 H-THR-PHE-LEU-LEU-ARG-NH2
英文名稱 TFLLR-NH2
CAS 197794-83-5
分子式 C31H53N9O6
分子量 647.81
MOL 文件 197794-83-5.mol
更新日期 2024/11/03 16:22:38
197794-83-5 結構式 197794-83-5 結構式

基本信息

中文別名
血酶受體
英文別名
TFLLR
TFLLR-NH2
TFLLR-AMIDE
TFLLR-NH2(2TFA)
(Thr1)-TRAP-5 amide
HYBRIDE HUMAN-XENOPE
THR-PHE-LEU-LEU-ARG-NH2
H-THR-PHE-LEU-LEU-ARG-NH2
(Thr1)-PAR-1 (1-5) amide (human)
REF DUPL: H-Thr-Phe-Leu-Leu-Arg-NH2

物理化學性質

密度1.31±0.1 g/cm3(Predicted)
儲存條件Desiccate at -20°C
酸度系數(shù)(pKa)12.10±0.45(Predicted)
形態(tài)粉末
水溶解性Soluble to 1 mg/ml in water

常見問題列表

生物活性
TFLLR-NH2是選擇性的PAR1激動劑,EC50值為1.9 μM。
靶點

EC50: 1.9 μM (PAR1)

體外研究

PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ]i above basal is detected in response to 10?μm TF-NH2(peak 196.5±20.4?nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.

體內研究

Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1?h and completely by 5?h. In wild-type but not PAR1 ?/? mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.

"197794-83-5" 相關產品信息
6028-28-0 354-38-1