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1956426-56-4

中文名稱 NULL
英文名稱 KN93 hydrochloride
CAS 1956426-56-4
分子式 C26H30Cl2N2O4S
更新日期 2023/03/20 15:41:27
分子量 537.5
MOL 文件 1956426-56-4.mol
1956426-56-4 結構式 1956426-56-4 結構式

基本信息

中文別名
鈣離子/鈣調蛋白依賴激酶II(CAMKII)抑制劑(KN-93 HYDROCHLORIDE)
英文別名
CS-1449
KN-93 HCl
KN93 hydrochloride
KN 93 hydrochloride
KN-93 (hydrochloride)
所屬類別
生物化工:激動劑抑制劑

物理化學性質

儲存條件-20°C儲存
溶解度DMF:10.0(Max Conc. mg/mL);18.6(Max Conc. mM)
DMSO:20.5(Max Conc. mg/mL);38.14(Max Conc. mM)
Water:0.45(Max Conc. mg/mL);0.84(Max Conc. mM)
形態(tài)結晶固體
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319
化合物 T21557價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/08/19HY-15465AKN-93 hydrochloride1956426-56-41mg558元
2024/08/19HY-15465AKN-93 hydrochloride1956426-56-45mg1100元
2024/08/19HY-15465AKN-93 hydrochloride1956426-56-410mM * 1mLin DMSO1301元

常見問題列表

生物活性
KN-93 hydrochloride是可滲透細胞,可逆和競爭性的抑制劑鈣調蛋白依賴性激酶II型 (CaMKII) 抑制劑,Ki 為370 nM。
靶點

Ki: 370 nM (CaMK-II)

體外研究

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

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