成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>195514-63-7

195514-63-7

中文名稱 AP1903
英文名稱 AP1903
CAS 195514-63-7
分子式 C78H98N4O20
分子量 1411.63
MOL 文件 195514-63-7.mol
更新日期 2024/12/26 16:50:18
195514-63-7 結(jié)構(gòu)式 195514-63-7 結(jié)構(gòu)式

基本信息

英文別名
AP1903
CS-1237
Rimiducid(AP1903)
AP1903 (Rimiducid
AP1903
RIMIDUCID
AP-1903
RIMIDUCID
AP-1903
AP 1903
2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, 2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester, (2S,2'S)-
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)1307.5±65.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO:97.05(Max Conc. mg/mL);68.75(Max Conc. mM)
Ethanol:120.58(Max Conc. mg/mL);85.42(Max Conc. mM)
酸度系數(shù)(pKa)13.70±0.46(Predicted)
形態(tài)固體
顏色White to light yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見(jiàn)問(wèn)題列表

生物活性
Rimiducid (AP1903) 是二聚化劑,其通過(guò)交聯(lián) FKBP 結(jié)構(gòu)域起作用,啟動(dòng) Fas 信號(hào)傳導(dǎo),引起凋亡。Rimiducid (AP1903) 使 Caspase 9 自殺開(kāi)關(guān)二聚化,并迅速誘導(dǎo)細(xì)胞凋亡 (apoptosis)。
靶點(diǎn)

EC50: 0.1 nM (FKBP, in HT1080 cells)
Fas receptor

體外研究

The human fibrosarcoma line HT1080 is engineered to express stably a fusion protein comprising a myristoylation sequence, two copies of F36V-FKBP, and the human first apoptosis signal (Fas) intracellular domain. Rimiducid (AP1903) elicits potent and dose-dependent apoptotic death of these engineered cells in culture, with an EC 50 of ≈0.1 nM. Maximal killing occurred in the presence of 3 to 10 nM Rimiducid (AP1903), and the IC 50 is approximately 0.2 nM. LV′VFas-transduced T lymphocytes expressing high levels of CD25 (top panel) are eliminated by with 66%±7.5% (n=10) efficiency. When cells are examined after CD25 expression returned to basal levels, 63%±4.7% (n=9) killing is observed after Rimiducid treatment.

體內(nèi)研究

Rimiducid (AP1903; i.v.,0.01, 0.1, 1, 10, and 100 mg/kg) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg.

"195514-63-7" 相關(guān)產(chǎn)品信息