188640-63-3
中文名稱
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
英文名稱
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
CAS
188640-63-3
分子式
C11H12ClNO2
分子量
225.671
MOL 文件
188640-63-3.mol
188640-63-3 結(jié)構(gòu)式
基本信息
中文別名
化合物P-ETHYNYLPHENYLALANINE HYDROCHLORIDE 英文別名
p-Ethynylphenylalanine hydrochloride4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM)
形態(tài)Solid
顏色Off-white to light yellow
水溶解性Water: < 0.1 mg/mL (insoluble)
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-23460A | 4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE p-Ethynylphenylalanine hydrochloride | 188640-63-3 | 50mg | 800元 |
| 2024/11/08 | HY-23460A | 4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE p-Ethynylphenylalanine hydrochloride | 188640-63-3 | 10mM * 1mLin DMSO | 880元 |
常見問題列表
生物活性
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一種高效、選擇性的，可逆、競爭性的色氨酸羥化酶 (TPH) 抑制劑，其 Ki 值為 32.6 μM。靶點(diǎn)
Ki: 32.6 μM (TPH)
體外研究
p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
體內(nèi)研究
p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase.
| Animal Model: | Male Sprague-Dawley rats (200 g) |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |