1883545-52-5
1883545-52-5 結(jié)構(gòu)式
基本信息
MM-102 (trifluoroacetate)
HMTASE INHIBITOR IX (TFA)
1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
| 報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-12220A | 1883545-52-5 MM-102 TFA | 1883545-52-5 | 2mg | 698元 |
| 2024/11/08 | HY-12220A | 1883545-52-5 MM-102 TFA | 1883545-52-5 | 5 mg | 1463元 |
| 2024/11/08 | HY-12220A | 1883545-52-5 MM-102 TFA | 1883545-52-5 | 10mM * 1mLin DMSO | 2173元 |
常見問題列表
IC50: 2.4 nM (MLL).
MM-102 (HMTase Inhibitor IX) inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. MM-102 (TFA), with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay withIC 50 =0.4-0.9 μM. MM-102 (HMTase Inhibitor IX) dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively. MM-102 (HMTase Inhibitor IX) has IC 50 =25 μM in both cell lines and completely inhibits cell growth in these cell lines at 75 μM. MM-102 (HMTase Inhibitor IX) effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.