1873376-49-8
中文名稱
1873376-49-8
英文名稱
CXCR2-IN-1
CAS
1873376-49-8
分子式
C19H20Cl2FN3O4S
分子量
476.35
MOL 文件
1873376-49-8.mol
1873376-49-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10905化合物CXCR2-IN-1
英文別名
CXCR2-IN-1CXCR2 inhibitor 1
N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)538.1±50.0 °C(Predicted)
密度1.528±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 5.4 mg/mL (11.34 mM)
酸度系數(shù)(pKa)5.02±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
CXCR2-IN-1是可滲透中樞神經(jīng)系統(tǒng)的CXCR2拮抗劑，pIC50值為9.3。靶點(diǎn)
|
CXCR2 9.3 (pIC 50 ) |
體外研究
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).
體內(nèi)研究
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.