184582-62-5

基本信息
3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺
3-[(2,7-二甲氧基吖啶-9-基)硫基]丙-1-胺
LDN-192960
LDN-192960 2HCl
LDN-192960 dihydrochloride
1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]-
LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine
3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride
3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/02/08 | HY-13455 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 LDN-192960 | 184582-62-5 | 1 mg | 1221元 |
2025/02/08 | HY-13455 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 LDN-192960 | 184582-62-5 | 10 mM * 1 mLin DMSO | 1445元 |
2025/02/08 | HY-13455 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 LDN-192960 | 184582-62-5 | 5mg | 2000元 |
常見問題列表
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.