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18444-66-1

中文名稱 葫蘆素 E
英文名稱 Cucurbitacin E
CAS 18444-66-1
分子式 C32H44O8
分子量 556.69
MOL 文件 18444-66-1.mol
更新日期 2024/12/19 09:33:50
18444-66-1 結(jié)構(gòu)式 18444-66-1 結(jié)構(gòu)式

基本信息

中文別名
葫蘆苦素E
葫蘆素 E
葫蘆素E對(duì)照品
葫蘆素E(標(biāo)準(zhǔn)品)
葫蘆素E(葫蘆苦素E)
葫蘆素 E, >99%
葫蘆素 E, 來源于甜瓜
英文別名
25-acetate
A-ELATERIN
Cucurbit E
α-Elaterine
CUCURBITACIN E
ALPHA-ELATERIN
cucurbitacine-e
alpha-elaterine
CUCURBITACIN E(SH)
CUCURBITACIN E hplc
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于甜瓜蒂。
熔點(diǎn)228-234°C
比旋光度D -59° (c = 0.7 in chloroform)
沸點(diǎn)545.56°C (rough estimate)
密度1.1059 (rough estimate)
折射率1.4900 (estimate)
儲(chǔ)存條件-20°C
溶解度DMSO:可溶15mg/mL,澄清
酸度系數(shù)(pKa)8.51±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
旋光性 (optical activity)[α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKeyNDYMQXYDSVBNLL-MUYMLXPFSA-N
LogP3.150 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
防范說明P301+P312+P330
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼25-22
安全說明1-22-45-24/25
危險(xiǎn)品運(yùn)輸編號(hào)3172
WGK Germany3
RTECS號(hào)RC6305500
海關(guān)編碼29153900
毒性LD50 orally in mice: 340 mg/kg (Albert)

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:用于治療慢性肝炎。1細(xì)胞毒與抗癌作用,2抗肝損害,3提高機(jī)體免疫功能。
用途2
葫蘆素 E具有保肝,抗腫瘤(人體鼻咽癌),催吐,增強(qiáng)免疫的作用。

常見問題列表

生物活性
Cucurbitacin E 是來自 Cucumic melo L 莖的一種天然化合物。Cucurbitacin E 顯著抑制 cyclin B1/CDC2 復(fù)合物的活性。
靶點(diǎn)

cyclin B1/CDC2

Autophagy

體外研究

To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5?μM) over a period of 24?h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5?μM) between 6 and 24?h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells.

體內(nèi)研究

A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS.

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