1810734-44-1
英文名稱(chēng)
Benzenesulfonamide, N-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N-methyl-4-(trifluoromethoxy)-
CAS
1810734-44-1
分子式
C25H24ClF3N2O3S
分子量
524.98
MOL 文件
1810734-44-1.mol
更新日期
2023/03/20 15:41:21
1810734-44-1 結(jié)構(gòu)式
基本信息
英文別名
TRC-766Benzenesulfonamide, N-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N-methyl-4-(trifluoromethoxy)-
物理化學(xué)性質(zhì)
沸點(diǎn)597.0±60.0 °C(Predicted)
密度1.341±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)0.83±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
TRC-766 是一種 RTC-5 (TRC-382) 的陰性對(duì)照。TRC-766 可結(jié)合蛋白磷酸酶 2A (PP2A)，但不激活磷酸酶。體外研究
As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability.