180300-43-0
基本信息
TAS 106
ETHYNYCYTIDINE
Ethynylcytidine
3'-Ethynylcytidine
3'-C-Ethynylcytidine
3’-β-C-Ethynylcytidine
cytidine, 3'-c-ethynyl-
3'-beta-C-Ethynylcytidine
Ethynylcytidine (TAS-106)
物理化學(xué)性質(zhì)
DMF:5.0(Max Conc. mg/mL);18.71(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.42(Max Conc. mM)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-16200 | 1KG | 備注:廠家優(yōu)勢供應(yīng) Ethynylcytidine | 180300-43-0 | 5mg | 1400元 |
2024/11/08 | HY-16200 | 1KG | 備注:廠家優(yōu)勢供應(yīng) Ethynylcytidine | 180300-43-0 | 10mM * 1mLin DMSO | 1540元 |
2024/11/08 | HY-16200 | 1KG | 備注:廠家優(yōu)勢供應(yīng) Ethynylcytidine | 180300-43-0 | 10mg | 2400元 |
常見問題列表
nucleoside antimetabolite
The IC 50 values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. These results suggest that the cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The differences in IC 50 values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appeares to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors. Even at the 4 h exposure time, Ethynylcytidine clearly shows potent cytotoxicity with IC 50 values at submicromolar concentrations in 4 of the 5 human tumors.
In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with an tumor growth inhibition rate (IR) on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine (TAS-106) on all three administration schedules. In particular, administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.