1802088-50-1
中文名稱
CS-2069
英文名稱
NCT-501
CAS
1802088-50-1
分子式
C21H32N6O3
分子量
416.52
MOL 文件
1802088-50-1.mol
更新日期
2024/11/04 16:13:57
1802088-50-1 結(jié)構(gòu)式
基本信息
中文別名
ALDH1A1抑制劑(NCT-501) 英文別名
CS-2069NCT-501
NCT-501 >=98% (HPLC)
1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)627.3±65.0 °C(Predicted)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
酸度系數(shù)(pKa)5.26±0.10(Predicted)
形態(tài)固體
顏色White to off-white
常見問(wèn)題列表
生物活性
NCT-501 是一種茶堿類的有效醛脫氫酶 1A1 (ALDH1A1) 選擇性抑制劑, 抑制 hALDH1A1 時(shí) IC50 值為 40 nM, 選擇性超過(guò)其它 ALDH 同工酶和其它脫氫酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 時(shí), IC50值 >57 UM)。靶點(diǎn)
IC50: 40 nM (hALDH1A1)
體外研究
NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant.
體內(nèi)研究
NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
| Animal Model: | 5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells) |
| Dosage: | 100μg/animal |
| Administration: | Intra-tumorally (i.t); every alternate day for 20 days |
| Result: | Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts. |