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17575-22-3

中文名稱 毛花苷C
英文名稱 LANATOSIDE C
CAS 17575-22-3
分子式 C49H76O20
分子量 985.12
MOL 文件 17575-22-3.mol
更新日期 2024/12/16 10:53:11
17575-22-3 結(jié)構(gòu)式 17575-22-3 結(jié)構(gòu)式

基本信息

中文別名
毛花苷C
毛花甙丙
毛花洋地黃苷
毛花洋地黃甙丙
地高辛EP雜質(zhì)H
去乙酰毛花洋地黃甙
去乙酰基毛花洋地黃甙
地高辛雜質(zhì)H(EP)
毛花苷C(甄準(zhǔn)不供應(yīng))
毛花甙C(地高辛雜質(zhì)H)
英文別名
Allocor
Celanid
isolanid
Ceglunat
Celanide
NSC 7533
isolanide
cedilanid
Ceglunate
Celadigal
所屬類別
原料藥:抗充血性心力衰竭藥

物理化學(xué)性質(zhì)

熔點(diǎn)272-274°C
比旋光度D20 +33.4 to +33.7° (200 mg dry weight in 10 ml alcohol)
沸點(diǎn)741.7°C (rough estimate)
密度1.42±0.1 g/cm3 (20 ºC 760 Torr)
折射率1.7630 (estimate)
儲(chǔ)存條件-20°C
溶解度DMSO:50.0(Max Conc. mg/mL);50.75(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);2.03(Max Conc. mM)
酸度系數(shù)(pKa)12.89±0.70(Predicted)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性吸濕性
LogP0.070

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H301-H330-H373
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25
安全說明36/37/39-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 2
WGK Germany3
RTECS號(hào)OE2100000

常見問題列表

生物活性
Lanatoside C 是具有抗病毒和抗腫瘤活性的強(qiáng)心苷。Lanatoside C 通過減弱 MAPK,Wnt,JAK-STAT和PI3K/AKT/mTOR信號(hào)通路,誘導(dǎo)G2/M細(xì)胞周期停滯并誘導(dǎo)自噬和細(xì)胞凋亡。
體外研究

Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71. Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.

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