175212-04-1
175212-04-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14986CMI977 (LDP977)
英文別名
LDP977CMI977
Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-
物理化學(xué)性質(zhì)
熔點(diǎn)106-107 °C
沸點(diǎn)524.8±60.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)10.12±0.50(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
CMI977 是一種有效的 5-Lipoxygenase (5-LO) 抑制劑。靶點(diǎn)
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5-LO
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體外研究
CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.