175139-41-0
中文名稱(chēng)
175139-41-0
英文名稱(chēng)
CP 316311
CAS
175139-41-0
分子式
C21H29NO2
分子量
327.46
MOL 文件
175139-41-0.mol
更新日期
2024/07/23 09:31:02
175139-41-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15008 英文別名
CP 316311Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-
物理化學(xué)性質(zhì)
熔點(diǎn)72.5-74 °C
沸點(diǎn)413.9±40.0 °C(Predicted)
密度1.007±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.63±0.30(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
CP 316311 是一種有效的，選擇性的 CRF1 receptor 拮抗劑，IC50 值為 6.8 nM。靶點(diǎn)
IC50: 6.8 nM (CRF1 receptor)
體外研究
CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent K i values of 7.6 and 8.5 nM, respectively.
體內(nèi)研究
CP 316311 (3.2 mg/kg) inhibits 125 I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic?pituitary?adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.