171964-73-1
中文名稱(chēng)
ZD-0892
英文名稱(chēng)
N-(4-METHOXYBENZOYL)-L-VALYL]-N-[(1S)-3,3,3-TR IFLUOR-1-ISOPROPYL2-OXOPROPYL]-L-PROLINAMIDE
CAS
171964-73-1
分子式
C24H32F3N3O5
分子量
499.52
MOL 文件
171964-73-1.mol
更新日期
2023/03/20 15:41:17
171964-73-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13389 英文別名
ZD-0892N-(4-METHOXYBENZOYL)-L-VALYL]-N-[(1S)-3,3,3-TR IFLUOR-1-ISOPROPYL2-OXOPROPYL]-L-PROLINAMIDE
L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)677.9±55.0 °C(Predicted)
密度1.227±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)12.20±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
ZD-0892是選擇性和有效的中性粒細(xì)胞彈性蛋白酶 (neutrophil elastase) 抑制劑，對(duì)于人嗜中性粒細(xì)胞彈性蛋白酶和豬胰彈性蛋白酶的 Ki 值分別為6.7和200 nM。靶點(diǎn)
Ki: 6.7 nM (Human neutrophil elastase), 200 nM (Human neutrophil elastase)
體內(nèi)研究
ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats.