170846-74-9
中文名稱
CHPG
英文名稱
CHPG
CAS
170846-74-9
分子式
C8H8ClNO3
分子量
201.61
MOL 文件
170846-74-9.mol
更新日期
2025/01/08 09:19:18
170846-74-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10809 英文別名
CHPG(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
α-amino-2-chloro-5-hydroxybenzeneacetic acid
Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26
WGK Germany3
常見(jiàn)問(wèn)題列表
生物活性
CHPG 是一個(gè)選擇性的 mGluR5 激動(dòng)劑，并且通過(guò) TSG-6/NF-κB 途徑減弱 BV2 小神經(jīng)膠質(zhì)細(xì)胞 SO2 誘導(dǎo)的氧化應(yīng)激和炎癥。 CHPG 通過(guò) ERK 和 Akt 途徑在體外和體內(nèi)預(yù)防創(chuàng)傷性腦損傷 (TBI)。靶點(diǎn)
|
mGlu 5
|
NF-κB
|
ERK
|
Akt
|
體外研究
CHPG (10-500?μM; 24?hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5?mM; 30?mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5?mM; 30?mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500?μM |
| Incubation Time: | 24?hours |
| Result: | Increased the cell viability. |
Apoptosis Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5?mM |
| Incubation Time: | 30?mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5?mM |
| Incubation Time: | 30?mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
體內(nèi)研究
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM |
| Administration: | Injection; for 7 days |
| Result: | Reduced significantly cerebral lesion volume. |