169474-77-5
中文名稱
FCE 28654
英文名稱
Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
CAS
169474-77-5
分子式
C25H35N2O7P
分子量
506.53
MOL 文件
169474-77-5.mol
169474-77-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13262 英文別名
FCE 28654Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
常見問題列表
生物活性
FCE 28654 是一種水溶的酰基 COA: 膽固醇?；D(zhuǎn)移酶 (ACAT) 抑制劑，在兔主動(dòng)脈、腸和猴肝臟的微粒體中，抑制 ACAT 的活性，IC50 值分別為 2.55，1.08 和 5.69 μM。靶點(diǎn)
IC50: 2.55 μM (ACAT, Rabbit aorta), 1.08 μM (ACAT, Rabbit intestine), 5.69 μM (ACAT, Monkey liver)
體外研究
FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC 50 s of 2.55, 1.08 and 5.69 μM, respcetively.
體內(nèi)研究
FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma.