169105-89-9
中文名稱
(3R,4R,5R)-5-(羥基甲基)哌啶-3,4-二醇鹽酸鹽
英文名稱
ISOFAGOMINE, HYDROCHLORIDE
CAS
169105-89-9
分子式
C6H14ClNO3
分子量
183.63
MOL 文件
169105-89-9.mol
169105-89-9 結構式
基本信息
中文別名
異桑葉生物堿(3R,4R,5R)-5-(羥基甲基)哌啶-3,4-二醇
(3R,4R,5R)-5-(羥基甲基)哌啶-3,4-二醇鹽酸鹽
英文別名
AfegostatD-Isofagomine
Unii-G23ap190ys
IsofagomineHydrochlroide
ISOFAGOMINE, HYDROCHLORIDE
5-Hydroxymethyl-3,4-piperidinediol
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride
所屬類別
有機原料：雜環(huán)化合物物理化學性質
沸點317.2±37.0 °C(Predicted)
密度1.279±0.06 g/cm3(Predicted)
儲存條件2-8°C(protect from light)
溶解度溶于二甲基亞砜
酸度系數(pKa)14.19±0.60(Predicted)
形態(tài)Oil
顏色Colorless to light yellow
常見問題列表
生物活性
Afegostat 是一種藥理學伴侶，高親和力且特異性和可逆地結合內質網 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。靶點
GCase
體內研究
Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.