166734-06-1
166734-06-1 結(jié)構(gòu)式
基本信息
中文別名
CIS-桑皮苷A順式-桑皮苷 A
英文別名
cis-Mulberroside Abeta-D-Glucopyranoside 3-[(1Z)-2-[4-(beta-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl
常見問題列表
生物活性
cis-Mulberroside A (Mulberroside D) 是 Mulberroside A 的順式異構(gòu)體。Mulberroside A 是桑樹 (Morus alba L.) 中的主要生物活性成分之一。Mulberroside A 可降低 TNF-α，IL-1β 和 IL-6 的表達(dá)，抑制 NALP3，caspase-1 和 NF-κB 的激活以及 ERK，JNK 和 p38 的磷酸化 。Mulberroside A 具有抗炎和抗細(xì)胞凋亡作用。Mulberroside A 對蘑菇酪氨酸酶 ( tyrosinase) 具有抑制活性，IC50 為 53.6 μM。體內(nèi)研究
Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice.
| Animal Model: | Male Kun-Ming mice (20±2 g) |
| Dosage: | 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight |
| Administration: | Orally initiated at 9:00 a.m. |
| Result: | 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal. |