16662-46-7
中文名稱
METHOXYVERAPAMIL HYDROCHLORIDE
英文名稱
METHOXYVERAPAMIL HYDROCHLORIDE
CAS
16662-46-7
分子式
C28H41ClN2O5
分子量
521.09
MOL 文件
16662-46-7.mol
更新日期
2023/03/20 15:41:24
16662-46-7 結(jié)構(gòu)式
基本信息
中文別名
鹽酸戈洛帕米 英文別名
D600D600, HCL
GALLOPAMIL
GALLOPAMIL HCL
(S)-Gallopamil
D 600 HYDROCHLORIDE
GALLOPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL HCL
METHOXYVERAPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
物理化學(xué)性質(zhì)
熔點(diǎn)145-148°
儲存條件-20°C儲存
溶解度DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
常見問題列表
生物活性
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) 是一種維拉帕米的甲氧基衍生物 (methoxy derivative of verapamil)，也是一種苯基烷基胺鈣 (phenylalkylamine calcium) 拮抗劑。Gallopamil hydrochloride 以濃度依賴性方式抑制酸分泌，IC50 為 10.9 μM。Gallopamil hydrochloride 是一種有效的抗心律不齊和血管擴(kuò)張劑。靶點(diǎn)
|
Ca 2+
|
體內(nèi)研究
Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.
| Animal Model: | Male Wistar rats weighing 290-370 g |
| Dosage: | 0.2 mg/kg |
| Administration: | i.v.; 5 min |
| Result: | Markedly reduced VT and totally prevented VF. |