166038-00-2
中文名稱
S-4-bromobenzylglutathione cyclopentyl diester
CAS
166038-00-2
分子式
C27H38BrN3O6S
分子量
612.58
MOL 文件
166038-00-2.mol
更新日期
2023/03/20 15:41:27
166038-00-2 結(jié)構(gòu)式
基本信息
中文別名
S-P-溴芐基谷胱甘肽環(huán)戊基二酯 英文別名
BrBzGCp2S-p-Bromobenzylglutathione cyclopentyl diester
S-4-bromobenzylglutathione cyclopentyl diester
S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
S-4-bromobenzylglutathione cyclopentyl diester價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 5mg | 800元 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 10mM * 1mLin DMSO | 1080元 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 10mg | 1400元 |
常見問題列表
生物活性
BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制劑，其 GC50 為 4.23 μM (HL-60 細(xì)胞)。BrBzGCp2 具有抗腫瘤和神經(jīng)保護(hù)活性。靶點(diǎn)
GC50: 4.23 μM (GLO1).
體內(nèi)研究
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior.
BrBzGCp2 pre-treatment decreases seizure duration.
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA
A
receptor activation.
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.
| Animal Model: | Male CD-1 mice. |
| Dosage: | 50 mg/kg. |
| Administration: | IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) |
| Result: | Allowed MG levels to accumulate for 2 hours |