1639933-78-0
中文名稱
LolCDE-IN-1
英文名稱
LolCDE-IN-1
CAS
1639933-78-0
分子式
C21H16FN3O
分子量
345.37
MOL 文件
1639933-78-0.mol
更新日期
2024/10/25 11:12:39
1639933-78-0 結(jié)構(gòu)式
基本信息
中文別名
化合物L(fēng)OLCDE-IN-1 英文別名
LolCDE-IN-1Pyridine, 4-[3-[3-[(4-fluorophenyl)methoxy]phenyl]-1H-pyrazol-4-yl]-
物理化學(xué)性質(zhì)
沸點(diǎn)529.9±50.0 °C(Predicted)
密度1.261±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 41.67 mg/mL (120.65 mM)
酸度系數(shù)(pKa)10.76±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
LolCDE-IN-1 是一種 LolCDE 復(fù)合物的抑制劑，具有抗菌活性。靶點(diǎn)
Bacterial
體外研究
LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane.
LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml.
LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.