1638957-17-1
中文名稱
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
英文名稱
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
CAS
1638957-17-1
分子式
C26H29N5O2
分子量
443.54
MOL 文件
1638957-17-1.mol
1638957-17-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28071 英文別名
ML395ML-395
ML 395
VU0468809
VU-0468809
VU 0468809
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
應(yīng)用領(lǐng)域
用途一
ML395, also known as VU0468809, is a potent PLD2 inhibitor. ML39 showed potent antiviral activity. ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). Moreover, ML395 possesses an attractive in vitro DMPK profile, improved physiochemical properties, ancillary pharmacology (Eurofins Panel) cleaner than any other reported PLD inhibitor, and has been found to possess interesting activity as an antiviral agent in cellular assays against a range of influenza strains (H1, H3, H5 and H7).