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1638750-96-5

中文名稱 ADU-S100銨鹽
英文名稱 ADU-S100 ammonium salt
CAS 1638750-96-5
分子式 C20H27N11O10P2S2
分子量 707.57
MOL 文件 1638750-96-5.mol
更新日期 2024/11/15 18:20:32
1638750-96-5 結(jié)構(gòu)式 1638750-96-5 結(jié)構(gòu)式

基本信息

中文別名
ADU-S100銨鹽
英文別名
MIW815 ammonium salt
ADU-S100 ammonium salt
ML RR-S2 CDA (ammonium salt)
STING-INDUCER-1 AMMONIUM SALT
ML RR-S2 CDA ammonium salt(ADU-S100)
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
所屬類別
有機(jī)原料:氨基化合物

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 15 mg/ml; Water: 12.5 mg/ml
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
ADU-S100銨鹽 價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-12885BADU-S100銨鹽
ADU-S100 ammonium salt
1638750-96-51mg3300元
2023/03/20HY-12885BADU-S100銨鹽
ADU-S100 ammonium salt
1638750-96-55 mg12000元
2023/03/20HY-12885BADU-S100銨鹽
ADU-S100 ammonium salt
1638750-96-510mM * 1mLin DMSO19129元

常見問題列表

生物活性
ADU-S100 ammonium salt (MIW815 ammonium salt) 是干擾素基因刺激物的激活劑 (STING),具有有效的抗腫瘤和免疫活性。
靶點(diǎn)

STING

體外研究

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

體內(nèi)研究

ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.

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